Allergens and molecular diagnostics of shellfish allergy
نویسندگان
چکیده
Shellfish belongs to "The Big 8" food groups causing allergy, which often does not outgrow during childhood. Shellfish is one of the main food allergens in adults and constitutes a diverse group of species subdivided into crustaceans and mollusks, which seem to include similar but also different allergens. Several pan-allergens are characterized in detail, including tropomyosin and arginine kinase, responsible for clinical cross-reactivity with other invertebrate allergen sources, embracing mites, insects, and parasites. Currently, at least seven different shellfish allergens have been identified, mostly from crustaceans. However, only three recombinant allergens are available for IgE-based routine diagnostic, including tropomyosin, arginine kinase, and sarcoplasmic Ca2+-binding protein. Other allergens include myosin light chain, troponin C, triosephosphate isomerase, and actin. This review summarizes the current advances on the molecular characterization of shellfish allergens, clinical cross-reactivity, and current diagnostic approaches for the management of this life-threatening disease.
منابع مشابه
Molecular and immunological characterization of shellfish allergens.
Shellfish (crustaceans and mollusks) have long been known as a common cause of allergic reactions to food. Like other food allergies, the allergic reactions to shellfish involve IgE-mediated Type I hypersensitivity. Biochemical and molecular studies have documented the major shrimp allergen is the muscle protein tropomyosin. Subsequent molecular cloning studies on lobsters and crabs have charac...
متن کاملUpdate on the diagnosis and treatment of shellfish allergy.
Shellfish allergy is a frequent, long-lasting, life-threatening disorder. As shellfish consumption increases, the number of allergic reactions to shellfish is expected to continue to rise as well. During the past decade, much has been learned about the allergens involved in shellfish allergy. Potential cross-reacting allergens between shellfish and other arthropods have been identified. As our ...
متن کاملHigh prevalence of shellfish and house dust mite allergies in Asia-Pacific: probably not just a coincidence.
The development of shellfish allergy usually begins in adulthood and tends to be a life-long problem. The prevalence of shellfish allergy is relatively high in Asian countries compared to the western world and symptoms may develop at the early age. 1 This phenomenon may simply reflect the geographic consumption of shellfish, however, other factors possibly play a role since low prevalence of sh...
متن کاملPrevalence of Aeroallergens and Food Allergens in Allergic Patients in Tehran, Iran
Background and Aims: Identification of different allergens is a major challenge in allergic diseases. Avoiding these allergens is known as one of the best types of treatment. The aim of this study is to determine the prevalence of aeroallergens and food allergens in patients with allergy by Skin Prick Test. Materials and Methods: A cross-sectional study was conducted on 255 patients with aller...
متن کاملCockroach, tick, storage mite and other arthropod allergies: Where do we stand with molecular allergy diagnostics?
Allergy – diagnostics – cockroach – tick – storage mite – arthropod Cockroach, tick, storage mite and other arthropod allergies: Where do we stand with molecular allergy diagnostics? Abstract Arthropods form a broad phylum within the animal kingdom, comprising widely varying members such as insects, arachnids, crabs and centipedes. In addition to common allergies to house dust mites or hy-menop...
متن کامل